Meet Dr. Spyridon Hasiakos, DDS, PhD
Endodontist
Dr. Spyridon Hasiakos is a board-eligible endodontist dedicated to helping patients preserve their natural teeth with advanced, compassionate care. He earned his dental degree from the University of Illinois–Chicago College of Dentistry and went on to complete specialty training in Endodontics at the UCLA School of Dentistry. There he gained extensive experience in root canal treatment, retreatment, and microsurgical procedures, refining the precision and skill he brings to every case.
As the first scholar selected for UCLA’s NIH-funded Dental Specialty PhD Program (DSPP), Dr. Hasiakos helped pioneer the program’s mission to develop dually trained clinician-scientists. He completed a PhD in Oral Biology, focusing on the role of the immune system in chronic inflammatory diseases. His research has been supported by multiple awards, including the NIH Loan Repayment Program Award, the UCLA Knaub Fellowship, and an NIH K08 career development grant. A published researcher in leading scientific journals, he has contributed to discoveries in basic science with translational potential for patient care.
Dr. Hasiakos is actively involved in the specialty as a member of the American Dental Association and the American Association of Endodontists, and he is pursuing board certification through the American Board of Endodontics.
Outside of dentistry, he enjoys traveling, photography, and music, and finds balance through time spent with family and friends in his hometown of Chicago.
Selected Publications
- Wu, B., Woo, J. S., Hasiakos, S., Pan, C., Cokus, S., Benincá, C., Stiles, L., Sun, Z., Pellegrini, M., Shirihai, O. S., Lusis, A. J., Srikanth, S., & Gwack, Y. (2025). Mitochondrial reactive oxygen species regulate acetyl-CoA flux between cytokine production and fatty acid synthesis in effector T cells. Cell Reports, 44(3), 115430.
- Howard, E., Hurrel, B., Helou, D., Shafieei-Hahani, P., Hasiakos, S., Painter, J., Srikanth, S., Gwack, Y., & Akbari, O. (2023). Orai inhibition modulates pulmonary ILC2 metabolomics and effector function in the amelioration of airway hyperreactivity. Nature Communications, 14(1), 5989. https://doi.org/10.1038/s41467-023-41065-4(PMCID: PMC10522697)
- Wu, B., Ramaiah, A., Garcia, G. Jr., Hasiakos, S., Arumugaswami, V., & Srikanth, S. (2022). ORAI1 limits SARS-CoV-2 infection by regulating tonic type I IFN signaling. Journal of Immunology, 208(1), 74–84. https://doi.org/10.4049/jimmunol.2100742 (PMCID: PMC8702473)
- Hasiakos, S., Gwack, Y., Kang, M., & Nishimura, I. (2021). Calcium signaling in T cells and chronic inflammatory disorders of the oral cavity. Journal of Dental Research, 100(7), 693–699. https://doi.org/10.1177/0022034521990652
- Hasiakos, S. P. (2024). Novel Clinical Insights: Demographic Study of Apical Periodontitis and the Translational Potential of CRAC Channels as Targets of Chronic Inflammatory Disease (Doctoral dissertation, UCLA). eScholarship.